Main Category: HIV / AIDS
Article Date: 17 Apr 2012 – 3:00 PDT
email to a friend printer friendly opinions
<!– rate article
Patient / Public:Healthcare Prof:
The acquired immunodeficiency syndrome (AIDS) pandemic is caused by the human immunodeficiency virus (HIV-1), which attacks the immune system and leaves infected individuals susceptible to opportunistic infections.
AIDS and HIV-1 are thought to have a relatively short history in humans, with the first infections likely occurring around the turn of the 20th century.
HIV-1 is derived from highly related simian immunodeficiency viruses (SIVs) that infect modern primates, including chimpanzees. SIVs must have crossed the species barrier to infect humans at some point in the past, but the molecular adaptations that permitted a new host are unknown.
Drs. Beatrice Hahn and Frank Kirchoff led an international research effort to understand what adaptations allow a chimpanzee strain of SIV to replicate in human tissues. They found that SIV is capable of replicating in human immune tissues, but that replication occurs at very low levels. By introducing a single amino acid change into the SIV Gag protein, a structural protein that makes up the viral capsid, the research team found that viral replication in cultured human tissues increased dramatically, while replication in chimpanzee-derived immune cells was decreased.
Their work indicates that species-specific adaptation of Gag is critical for viral replication efficiency and suggests that changes in Gag potentially played a role in the emergence of HIV/AIDS.
Efficient SIVcpz replication in human lymphoid tissue requires viral matrix protein adaptation
View this article at: http://www.jci.org/articles/view/61429?key=b299fdfbdc1c9633aa06
Please use one of the following formats to cite this article in your essay, paper or report:
Please note: If no author information is provided, the source is cited instead.
Add Your Opinion On This Article
‘SIV And HIV: Replication Of Immunodeficiency Virus In Humans’
Please note that we publish your name, but we do not publish your email address. It is only used to let
If you write about specific medications or operations, please do not name health care professionals by name.
All opinions are moderated before being included (to stop spam)
Contact Our News Editors
For any corrections of factual information, or to contact the editors please use our feedback form.
Please send any medical news or health news press releases to:
Note: Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a health care
professional. For more information, please read our terms and conditions.
Terms and Conditions
MediLexicon International Ltd
Bexhill-on-Sea, United Kingdom
MediLexicon International Ltd © 2004-2012 All rights reserved.
Article source: http://www.medicalnewstoday.com/releases/244170.php